Lee,Jung-Sook

Institution: Korea Research Institute of Bioscience and Biotechnology, Korea

Research Interests: Gene, Patients, Cancer, Cell, DNA, Time, Genes, Lung, Water, Treatment, Role, Lung Cancer, Chemotherapy, Cells, Oxygen, Strain, mRNA, Disease, Survival, Risk

Publications

Information and abstracts for author publications
Published Date	Impact	Publication
02/27/2012	18.4	Journal of clinical oncology : official journal of the American Society of Clinical Oncology First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung.	Abstract
09/08/2009	18.4	Journal of clinical oncology : official journal of the American Society of Clinical Oncology Randomized, placebo-controlled, phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer.	Abstract
12/12/2011	15.4	Advanced materials (Deerfield Beach, Fla.) Structural and electrical characterization of a block copolymer-based unipolar nonvolatile memory device.	Abstract
02/17/2011	13.8	Journal of the National Cancer Institute Sex hormone levels and risks of estrogen receptor-negative and estrogen receptor-positive breast cancers.	Abstract
12/09/2009	13.2	Nano letters Synthesis and thermally reversible assembly of DNA-gold nanoparticle cluster conjugates.	Abstract
08/11/2010	13.2	Nano letters Flexible organic transistor memory devices.	Abstract
08/16/2012	13.2	Nano letters Quantitative thermopower profiling across a silicon p-n junction with nanometer resolution.	Abstract
03/18/2012	11.7	Hepatology (Baltimore, Md.) Sixty-five gene-based risk score classifier predicts overall survival in hepatocellular carcinoma.	Abstract
05/15/2013	11.7	Hepatology (Baltimore, Md.) Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520.	Abstract
10/19/2011	10.8	ACS nano Quantitative measurement with scanning thermal microscope by preventing the distortion due to the heat transfer through the air.	Abstract
12/15/2011	10.3	EMBO molecular medicine Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer.	Abstract
10/13/2011	10.1	Gut Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer.	Abstract
12/08/2008	9.9	Blood Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation.	Abstract
10/19/2012	9.2	The EMBO journal Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment.	Abstract
11/12/2010	8.8	Cell death and differentiation PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation.	Abstract
02/16/2012	8.3	Small (Weinheim an der Bergstrasse, Germany) Uni-molecular hollow micelles from amphiphilic homopolymer poly(2-(4-vinylphenyl)pyridine).	Abstract
10/15/2012	8	Nucleic acids research Suppression and recovery of BRCA1-mediated transcription by HP1γ via modulation of promoter occupancy.	Abstract
06/02/2009	7.9	Cancer research Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence.	Abstract
03/29/2011	7.7	Clinical cancer research : an official journal of the American Association for Cancer Research Gene expression signature-based prognostic risk score in gastric cancer.	Abstract
03/17/2011	7.7	Clinical cancer research : an official journal of the American Association for Cancer Research A randomized phase II study of gefitinib plus simvastatin versus gefitinib alone in previously treated patients with advanced non-small cell lung cancer.	Abstract
06/08/2011	7.7	Clinical cancer research : an official journal of the American Association for Cancer Research Circulating cell-free DNA in plasma of never smokers with advanced lung adenocarcinoma receiving gefitinib or standard chemotherapy as first-line therapy.	Abstract
09/28/2010	7.6	Human molecular genetics A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population.	Abstract
04/20/2010	7.3	The American journal of gastroenterology Pancreatic resection guided by preoperative intraductal ultrasonography for intraductal papillary mucinous neoplasm.	Abstract
09/18/2013	7	Mucosal immunology Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury.	Abstract
01/09/2013	6.8	ChemSusChem TiN nanoparticles on CNT-graphene hybrid support as noble-metal-free counter electrode for quantum-dot-sensitized solar cells.	Abstract
08/27/2012	6.8	ChemSusChem Photocatalytic and photoelectrochemical water oxidation over metal-doped monoclinic BiVO(4) photoanodes.	Abstract
10/24/2011	6.8	JACC. Cardiovascular interventions Clinical utility of regadenoson for assessing fractional flow reserve.	Abstract
04/14/2011	6.7	Chemical communications (Cambridge, England) Palladium-nickel alloys loaded on tungsten carbide as platinum-free anode electrocatalysts for polymer electrolyte membrane fuel cells.	Abstract
10/04/2010	6.7	Chemical communications (Cambridge, England) Platinum-free tungsten carbides as an efficient counter electrode for dye sensitized solar cells.	Abstract
06/27/2011	6.7	Chemical communications (Cambridge, England) Rapid (∼10 min) synthesis of single-crystalline, nanorice TiO2 mesoparticles with a high photovoltaic efficiency of above 8%.	Abstract
08/05/2010	6.7	Chemical communications (Cambridge, England) Salt concentration-induced dehybridisation of DNA-gold nanoparticle conjugate assemblies for diagnostic applications.	Abstract
07/13/2009	6.7	Chemical communications (Cambridge, England) Reversibly interchangeable, chain-wrapped micelles and vesicles of an amphiphilic rod-coil block copolymer.	Abstract
01/09/2012	6.7	Chemical communications (Cambridge, England) Modulation of the translocation of peptides through nanopores by the application of an AC electric field.	Abstract
10/21/2011	6.7	Chemical communications (Cambridge, England) "Governing initiation-supporting termination" in chiral poly(n-hexyl isocyanate).	Abstract
04/27/2012	6.5	Plant physiology Genetic evidence for the reduction of brassinosteroid levels by a BAHD acyltransferase-like protein in Arabidopsis.	Abstract
08/04/2011	6.4	Annals of oncology : official journal of the European Society for Medical Oncology / ESMO Adjuvant capecitabine chemotherapy using a tailored-dose strategy in elderly patients with colon cancer.	Abstract
07/10/2012	6.4	Annals of oncology : official journal of the European Society for Medical Oncology / ESMO A randomized phase II study of irinotecan plus cisplatin versus irinotecan plus capecitabine with or without isosorbide-5-mononitrate in advanced non-small-cell lung cancer.	Abstract
09/14/2012	6.4	Haematologica The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe.	Abstract
03/13/2012	6.4	Journal of nuclear medicine : official publication, Society of Nuclear Medicine Initial results of simultaneous PET/MRI experiments with an MRI-compatible silicon photomultiplier PET scanner.	Abstract
07/02/2012	6.4	Oncogene FIP200 inhibits β-catenin-mediated transcription by promoting APC-independent β-catenin ubiquitination.	Abstract
10/26/2009	6.4	Oncogene Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species.	Abstract
11/29/2013	6.1	Biotechnology for biofuels Optimization of NaOH-catalyzed steam pretreatment of empty fruit bunch.	Abstract
07/16/2013	6.1	Angiogenesis Quantitative positron emission tomography imaging of angiogenesis in rats with forelimb ischemia using (68)Ga-NOTA-c(RGDyK).	Abstract
08/28/2013	5.9	Nanoscale Hollow flower micelles from a diblock copolymer.	Abstract
10/16/2013	5.9	Analytical chemistry Masking nanoparticle surfaces for sensitive and selective colorimetric detection of proteins.	Abstract
06/25/2013	5.9	Analytical chemistry Library approach for reliable synthesis and properties of DNA-gold nanorod conjugates.	Abstract
09/01/2011	5.9	Analytical chemistry Designed hybridization properties of DNA-gold nanoparticle conjugates for the ultraselective detection of a single-base mutation in the breast cancer gene BRCA1.	Abstract
01/28/2011	5.8	Journal of immunology (Baltimore, Md. : 1950) CX3CR1+ lung mononuclear phagocytes spatially confined to the interstitium produce TNF-α and IL-6 and promote cigarette smoke-induced emphysema.	Abstract
12/21/2009	5.7	Journal of thrombosis and haemostasis : JTH The incidence, risk factors and prognostic implications of venous thromboembolism in patients with gastric cancer.	Abstract
08/19/2010	5.7	Radiology Allogeneic renal graft rejection in a rat model: in vivo MR imaging of the homing trait of macrophages.	Abstract
10/28/2013	5.7	Radiology Rheumatoid arthritis-associated interstitial lung disease: radiologic identification of usual interstitial pneumonia pattern.	Abstract
05/10/2012	5.7	Carcinogenesis FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair.	Abstract
11/08/2012	5.7	Carcinogenesis Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.	Abstract
03/02/2009	5.7	Human mutation MedRefSNP: a database of medically investigated SNPs.	Abstract
09/11/2008	5.3	Environment international Enhancement of arsenic mobility by indigenous bacteria from mine tailings as response to organic supply.	Abstract
04/25/2013	5.2	Environmental science & technology Whole spectrum of cytochrome P450 genes and molecular responses to water-accommodated fractions exposure in the marine medaka.	Abstract
11/24/2010	5.2	Endoscopy Hybrid natural orifice transluminal endoscopic surgery: endoscopic full-thickness resection of early gastric cancer and laparoscopic regional lymph node dissection--14 human cases.	Abstract
11/10/2011	5	Thrombosis and haemostasis Different characteristics and prognostic impact of deep-vein thrombosis / pulmonary embolism and intraabdominal venous thrombosis in colorectal cancer patients.	Abstract
03/11/2009	5	Thrombosis and haemostasis Vascular events in Korean patients with myeloproliferative neoplasms and their relationship to JAK2 mutation.	Abstract
01/12/2010	5	Bioresource technology Production of bioethanol from lignocellulose: Status and perspectives in Korea.	Abstract
04/11/2009	5	Bioresource technology Esterification of free fatty acids using water-tolerable Amberlyst as a heterogeneous catalyst.	Abstract
07/31/2012	5	Bioresource technology Enhancement of enzymatic digestibility of Eucalyptus grandis pretreated by NaOH catalyzed steam explosion.	Abstract
03/28/2011	4.8	Antimicrobial agents and chemotherapy Mutations in gidB confer low-level streptomycin resistance in Mycobacterium tuberculosis.	Abstract
11/30/2010	4.8	Cancer A phase 2 study of irinotecan, cisplatin, and simvastatin for untreated extensive-disease small cell lung cancer.	Abstract
08/15/2013	4.7	PLoS neglected tropical diseases Multi-gene detection and identification of mosquito-borne RNA viruses using an oligonucleotide microarray.	Abstract
07/22/2011	4.7	American journal of hematology Prevalence of monoclonal gammopathy of undetermined significance in an elderly urban Korean population.	Abstract
07/21/2009	4.6	Macromolecular rapid communications Preparation of ag-embedded polystyrene nanospheres and nanocapsules by miniemulsion polymerization.	Abstract
05/13/2011	4.6	Macromolecular rapid communications Au/CdS Hybrid Nanoparticles in Block Copolymer Micellar Shells.	Abstract
07/26/2011	4.6	Macromolecular rapid communications Synthesis of Well-defined Amphiphilic Block Copolymers by Organotellurium-Mediated Living Radical Polymerization (TERP).	Abstract
09/13/2012	4.6	Macromolecular rapid communications Arrangement of C60 via the self-assembly of post-functionalizable polyisocyanate block copolymer.	Abstract
04/21/2009	4.6	Macromolecular rapid communications Well-Organized CdS/C(60) in Block Copolymer Micellar Cores.	Abstract
06/05/2012	4.5	The pharmacogenomics journal A genome-wide association study for irinotecan-related severe toxicities in patients with advanced non-small-cell lung cancer.	Abstract
10/27/2009	4.5	The pharmacogenomics journal Association of SUMO1 and UBC9 genotypes with tumor response in non-small-cell lung cancer treated with irinotecan-based chemotherapy.	Abstract
03/12/2013	4.5	The pharmacogenomics journal A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy.	Abstract
09/12/2012	4.5	Proteomics Secretome analysis of ionizing radiation-induced senescent cancer cells reveals that secreted RKIP plays a critical role in neighboring cell migration.	Abstract
03/26/2008	4.4	Breast cancer research and treatment Weight changes after adjuvant treatment in Korean women with early breast cancer.	Abstract
08/11/2011	4.4	Breast cancer research and treatment First generation prognostic gene signatures for breast cancer predict both survival and chemotherapy sensitivity and identify overlapping patient populations.	Abstract
05/21/2009	4.3	Annals of the New York Academy of Sciences Expression of gonadotropin alpha, follicle-stimulating hormone beta, and luteinizing hormone beta genes of the hermaphroditic fish Kryptolebias marmoratus exposed to octylphenol, 17beta estradiol, and tamoxifen.	Abstract
05/21/2009	4.3	Annals of the New York Academy of Sciences Cloning and expression of Vitellogenin 2 gene from the intertidal copepod Tigriopus japonicus.	Abstract
10/10/2011	4.2	The Analyst Silicon nanowire ion sensitive field effect transistor with integrated Ag/AgCl electrode: pH sensing and noise characteristics.	Abstract
05/03/2012	4.2	Journal of innate immunity Heterogeneity of lung mononuclear phagocytes in chronic obstructive pulmonary disease.	Abstract
08/26/2009	4.2	Langmuir : the ACS journal of surfaces and colloids Au-coated 3-D nanoporous titania layer prepared using polystyrene-b-poly(2-vinylpyridine) block copolymer nanoparticles.	Abstract
06/30/2009	4.2	Langmuir : the ACS journal of surfaces and colloids Formation of intermicellar-chained and cylindrical micellar networks from an amphiphilic rod-coil block copolymer: poly(n-hexyl isocyanate)-block-poly(2-vinylpyridine).	Abstract
06/10/2010	4.2	Langmuir : the ACS journal of surfaces and colloids Effect of solvent composition on transformation of micelles to vesicles of rod-coil poly(n-hexyl isocyanate-block-2-vinylpyridine) diblock copolymers.	Abstract
07/06/2012	4.2	Langmuir : the ACS journal of surfaces and colloids Simple synthesis of palladium nanoparticles, β-phase formation, and the control of chain and dipole orientations in palladium-doped poly(vinylidene fluoride) thin films.	Abstract
12/02/2011	4.2	Langmuir : the ACS journal of surfaces and colloids Synthesis of length-controlled polyvalent silver nanowire-DNA conjugates for sensitive and selective detection of DNA targets.	Abstract
05/09/2009	4.2	Annals of surgical oncology Developing an institutional protocol guideline for laparoscopy-assisted distal gastrectomy.	Abstract
10/06/2010	4.1	International journal of radiation oncology, biology, physics Randomized trial of postoperative adjuvant therapy in Stage II and III rectal cancer to define the optimal sequence of chemotherapy and radiotherapy: 10-year follow-up.	Abstract
12/29/2008	4.1	International journal of radiation oncology, biology, physics A Phase II study of synchronous three-dimensional conformal boost to the gross tumor volume for patients with unresectable Stage III non-small-cell lung cancer: results of Korean Radiation Oncology Group 0301 study.	Abstract
09/07/2012	4.1	PloS one Development and validation of a prognostic gene-expression signature for lung adenocarcinoma.	Abstract
12/27/2011	4.1	PloS one Duffy antigen receptor for chemokines mediates chemokine endocytosis through a macropinocytosis-like process in endothelial cells.	Abstract
02/07/2013	4.1	PloS one Individualized risk prediction model for lung cancer in Korean men.	Abstract
11/30/2010	4.1	PloS one Prognostic biomarkers for esophageal adenocarcinoma identified by analysis of tumor transcriptome.	Abstract
11/29/2011	4.1	PloS one Atmospheric-pressure plasma jet induces apoptosis involving mitochondria via generation of free radicals.	Abstract
10/01/2011	4.1	Cellular signalling Cellular signaling and biological functions of R-spondins.	Abstract
10/26/2010	4	Surgical endoscopy Outcome of palliative self-expanding metal stent placement in malignant colorectal obstruction according to stent type and manufacturer.	Abstract
08/18/2009	4	Nanotechnology The fabrication of nanopatterns with Au nanoparticles-embedded micelles via nanoimprint lithography.	Abstract
09/22/2010	4	Nanotechnology Growth of single crystalline barium titanate nanowires from TiO2 seeds deposited on conducting glass.	Abstract
12/17/2013	4	Nanotechnology Achieving high sensitivity in hybrid photodetectors based on an organic single crystal and an inorganic nanocrystal array.	Abstract
09/26/2012	4	Nanotechnology Electron states in a silicon nanowire in the presence of surface potential and field.	Abstract
03/14/2012	4	Nanotechnology Morphology controlled fabrication and ferroelectric properties of vertically aligned one-dimensional lead titanate nanoarrays.	Abstract
01/28/2011	4	Epilepsia Neuroimaging in identifying focal cortical dysplasia and prognostic factors in pediatric and adolescent epilepsy surgery.	Abstract
08/30/2012	3.8	Journal of bacteriology Draft genome sequence of the human pathogen Halomonas stevensii S18214T.	Abstract
11/12/2012	3.8	Journal of bacteriology Draft genome sequence of the extremely halophilic archaeon Halogranum salarium B-1T.	Abstract
05/13/2013	3.8	Aquatic toxicology (Amsterdam, Netherlands) Co-expression of antioxidant enzymes with expression of p53, DNA repair, and heat shock protein genes in the gamma ray-irradiated hermaphroditic fish Kryptolebias marmoratus larvae.	Abstract
12/04/2009	3.8	Aquatic toxicology (Amsterdam, Netherlands) UV radiation in marine ectotherms: molecular effects and responses.	Abstract
02/19/2012	3.8	Aquatic toxicology (Amsterdam, Netherlands) P-glycoprotein (P-gp) in the monogonont rotifer, Brachionus koreanus: molecular characterization and expression in response to pharmaceuticals.	Abstract
12/17/2010	3.8	Aquatic toxicology (Amsterdam, Netherlands) Ultraviolet B retards growth, induces oxidative stress, and modulates DNA repair-related gene and heat shock protein gene expression in the monogonont rotifer, Brachionus sp.	Abstract
05/07/2011	3.8	Aquatic toxicology (Amsterdam, Netherlands) Bisphenol A modulates expression of sex differentiation genes in the self-fertilizing fish, Kryptolebias marmoratus.	Abstract
11/20/2009	3.7	The journal of physical chemistry. B On the asymptotic properties of a hard sphere fluid.	Abstract
07/12/2012	3.7	Clinical nuclear medicine Gelatinous degeneration of the bone marrow mimicking osseous metastasis on 18F-FDG PET/CT.	Abstract
05/27/2011	3.7	The British journal of dermatology The gene expression profile of matrix metalloproteinases and their inhibitors in children with Henoch-Schönlein purpura.	Abstract
02/26/2010	3.7	Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer First-line gefitinib treatment for patients with advanced non-small cell lung cancer with poor performance status.	Abstract
02/15/2012	3.7	Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer Hypoxia-inducible factor-1α and excision repair cross-complementing 1 in patients with small cell lung cancer who received front-line platinum-based chemotherapy: a retrospective study.	Abstract
06/24/2009	3.7	Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer Early prediction of response to first-line therapy using integrated 18F-FDG PET/CT for patients with advanced/metastatic non-small cell lung cancer.	Abstract
01/11/2011	3.7	Food chemistry Characterisation of a new antihypertensive angiotensin I-converting enzyme inhibitory peptide from Pleurotus cornucopiae.	Abstract
12/21/2009	3.6	Molecular phylogenetics and evolution Mitochondrial genome of Thais clavigera (Mollusca: Gastropoda): affirmation of the conserved, ancestral gene pattern within the mollusks.	Abstract
02/07/2013	3.6	Optics express Dependence of efficiencies in GaN-based vertical blue light-emitting diodes on the thickness and doping concentration of the n-GaN layer.	Abstract
12/09/2009	3.6	Optics express Optical gain and penalty characteristics of a fiber-Bragg-grating based active optical-add-drop multiplexer.	Abstract
03/26/2009	3.6	The Journal of molecular diagnostics : JMD Comparison of circulating plasma DNA levels between lung cancer patients and healthy controls.	Abstract
05/10/2013	3.6	Physical chemistry chemical physics : PCCP A physicochemical mechanism of chemical gas sensors using an AC analysis.	Abstract
08/21/2013	3.6	Physical chemistry chemical physics : PCCP Isoindigo-based small molecules for high-performance solution-processed organic photovoltaic devices: the electron donating effect of the donor group on photo-physical properties and device performance.	Abstract
03/18/2009	3.6	Physical chemistry chemical physics : PCCP Electrical conductivity-defect structure correlation of variable-valence and fixed-valence acceptor-doped BaTiO(3) in quenched state.	Abstract
11/23/2010	3.5	FEBS letters Acetyltransferase p300 regulates NBS1-mediated DNA damage response.	Abstract
07/04/2012	3.5	FEBS letters Methamphetamine binds to α-synuclein and causes a conformational change which can be detected by nanopore analysis.	Abstract
06/02/2009	3.5	Journal of neurology Nerve conduction studies in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.	Abstract
06/05/2012	3.4	Lung cancer (Amsterdam, Netherlands) Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 mutation.	Abstract
01/20/2009	3.4	Lung cancer (Amsterdam, Netherlands) Epidermal growth factor receptor tyrosine kinase inhibitors as a first-line therapy for never-smokers with adenocarcinoma of the lung having asymptomatic synchronous brain metastasis.	Abstract
11/20/2012	3.4	Lung cancer (Amsterdam, Netherlands) A phase II study of sunitinib in patients with relapsed or refractory small cell lung cancer.	Abstract
01/24/2008	3.4	Lung cancer (Amsterdam, Netherlands) Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer.	Abstract
12/18/2011	3.4	Lung cancer (Amsterdam, Netherlands) Clinical outcomes of leptomeningeal metastasis in patients with non-small cell lung cancer in the modern chemotherapy era.	Abstract
12/10/2008	3.4	Marine biotechnology (New York, N.Y.) Inhibitory effects of Fucoidan in 3T3-L1 adipocyte differentiation.	Abstract
07/18/2012	3.4	The Journal of thoracic and cardiovascular surgery The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer.	Abstract
05/26/2011	3.4	Systematic and applied microbiology Halogranum salarium sp. nov., a halophilic archaeon isolated from sea salt.	Abstract
06/15/2012	3.4	Systematic and applied microbiology Nakamurella panacisegetis sp. nov. and proposal for reclassification of Humicoccus flavidus Yoon et al., 2007 and Saxeibacter lacteus Lee et al., 2008 as Nakamurella flavida comb. nov. and Nakamurella lactea comb. nov.	Abstract
03/18/2009	3.3	Acta oncologica (Stockholm, Sweden) Chemotherapy-induced transient CEA and CA19-9 surges in patients with metastatic or recurrent gastric cancer.	Abstract
11/26/2013	3.3	Fish & shellfish immunology Immune gene discovery in the crucian carp Carassius auratus.	Abstract
10/03/2013	3.3	Developmental and comparative immunology Transcriptional profiles of Rel/NF-κB, inhibitor of NF-κB (IκB), and lipopolysaccharide-induced TNF-α factor (LITAF) in the lipopolysaccharide (LPS) and two Vibrio sp.-exposed intertidal copepod, Tigriopus japonicus.	Abstract
03/22/2012	3.2	Journal of environmental management Immobilizer-assisted management of metal-contaminated agricultural soils for safer food production.	Abstract
12/24/2010	3.2	Transfusion Advanced glycation end products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for advanced glycation end products.	Abstract
08/09/2011	3.2	Transfusion Acute exacerbation of subclinical pulmonary fibrosis after red blood cell transfusion: a case report.	Abstract
08/24/2010	3.2	Transfusion Red blood cell microparticles show altered inflammatory chemokine binding and release ligand upon interaction with platelets.	Abstract
07/06/2013	3.2	Journal of neuro-oncology Impact of EGFR tyrosine kinase inhibitors versus chemotherapy on the development of leptomeningeal metastasis in never smokers with advanced adenocarcinoma of the lung.	Abstract
05/07/2011	3.2	Chemosphere Cu/Zn- and Mn-superoxide dismutase (SOD) from the copepod Tigriopus japonicus: molecular cloning and expression in response to environmental pollutants.	Abstract
10/07/2013	3.2	Chemosphere Development of enzyme-linked immunosorbent assay (ELISA) for glutathione S-transferase (GST-S) protein in the intertidal copepod Tigriopus japonicus and its application for environmental monitoring.	Abstract
05/25/2013	3.2	Chemosphere Expression profile analysis of antioxidative stress and developmental pathway genes in the manganese-exposed intertidal copepod Tigriopus japonicus with 6K oligochip.	Abstract
03/19/2009	3.1	Head & neck Advanced squamous cell carcinoma of the oropharynx: efficacy of positron emission tomography and computed tomography for determining primary tumor response during induction chemotherapy.	Abstract
10/15/2013	3.1	BMC infectious diseases Utility of the REBA MTB-Rifa® assay for rapid detection of rifampicin resistant Mycobacterium tuberculosis.	Abstract
12/21/2009	3	Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association Remnant posterior cruciate ligament-augmenting stent procedure for injuries in the acute or subacute stage.	Abstract
06/23/2012	3	Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association Hybrid tibial fixation for anterior cruciate ligament reconstruction with Achilles tendon allograft.	Abstract
08/21/2010	3	Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association Bilateral discoid lateral meniscus in knees: evaluation of the contralateral knee in patients with symptomatic discoid lateral meniscus.	Abstract
08/21/2009	3	Analytical biochemistry Nanopore detection of antibody prion interactions.	Abstract
06/29/2010	3	Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine In vivo MR evaluation of the effect of the CCR2 antagonist on macrophage migration.	Abstract
10/13/2009	3	Anaesthesia The effect of intrathecal fentanyl on Cerebral State Index-guided sedation during spinal anaesthesia.	Abstract
05/17/2010	3	Anaesthesia Tracheal intubation using the Airtraq: a comparison with the lightwand.	Abstract
07/29/2010	2.9	The journal of physical chemistry. A Structure and conformational stability of protonated dialanine.	Abstract
11/14/2013	2.9	Clinical lung cancer Clinical significance of heterogeneity in response to retreatment with epidermal growth factor receptor tyrosine kinase inhibitors in patients with lung cancer acquiring secondary resistance to the drug.	Abstract
12/29/2012	2.9	Clinical lung cancer Prognostic value of gross tumor volume for definitive radiation therapy in patients with locoregionally recurrent non-small-cell lung cancer after surgical resection.	Abstract
01/31/2011	2.9	Archives of biochemistry and biophysics Cloning and biochemical characterization of Staphylococcus aureus type IA DNA topoisomerase comprised of distinct five domains.	Abstract
09/25/2013	2.9	Molecular biology reports Different anti-apoptotic effects of normal and asthmatic serum on normal eosinophil apoptosis depending on house dust mite-specific IgE.	Abstract
01/05/2013	2.9	Molecular biology reports A (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano[3,2-g]-chromen-3-yl-ester, attenuates the development of atopic dermatitis-like lesions in NC/Nga mice.	Abstract
09/10/2009	2.9	Molecular biology reports A comparative analysis of the complete mitochondrial genome of the Eurasian otter Lutra lutra (Carnivora; Mustelidae).	Abstract
10/23/2013	2.9	Journal of gastroenterology and hepatology Comparison of clinical effectiveness of the emergent colonoscopy in patients with hematochezia according to the type of bowel preparation.	Abstract
01/11/2012	2.9	Vox sanguinis Red cell microparticle enumeration: validation of a flow cytometric approach.	Abstract
12/23/2008	2.8	Cancer chemotherapy and pharmacology Fixed-dose rate infusion of gemcitabine and weekly cisplatin in elderly or poor performance status patients with unresectable non-small cell lung cancer.	Abstract
02/25/2010	2.8	Cancer chemotherapy and pharmacology Phase II study of erlotinib for chemotherapy-naïve patients with advanced or metastatic non-small cell lung cancer who are ineligible for platinum doublets.	Abstract
02/06/2013	2.8	Physics in medicine and biology Continuous depth-of-interaction measurement in a single-layer pixelated crystal array using a single-ended readout.	Abstract
05/30/2012	2.8	Physics in medicine and biology SiPM-PET with a short optical fiber bundle for simultaneous PET-MR imaging.	Abstract
07/03/2012	2.8	Environmental toxicology and chemistry / SETAC Gamma irradiation-induced oxidative stress and developmental impairment in the hermaphroditic fish, Kryptolebias marmoratus embryo.	Abstract
04/10/2009	2.8	American journal of surgery Influence of T3 or T4 sympathicotomy for palmar hyperhidrosis.	Abstract
03/21/2011	2.7	Nanoscale research letters Two-phase numerical model for thermal conductivity and convective heat transfer in nanofluids.	Abstract
05/10/2010	2.7	Biochemistry and cell biology = Biochimie et biologie cellulaire Nanopore analysis of the interaction of metal ions with prion proteins and peptides.	Abstract
05/24/2013	2.7	Drugs & aging Medication (re)fill adherence measures derived from pharmacy claims data in older Americans: a review of the literature.	Abstract
08/31/2012	2.7	Environmental science and pollution research international Molecular cloning and expression of novel metallothionein (MT) gene in the polychaete Perinereis nuntia exposed to metals.	Abstract
01/24/2011	2.6	Cancer DNA repair gene polymorphisms and benefit from gefitinib in never-smokers with lung adenocarcinoma.	Abstract
03/30/2013	2.6	Journal of biomedical materials research. Part A Mechanical properties of decellularized tendon cultured by cyclic straining bioreactor.	Abstract
11/22/2012	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Evaluation of biomarker potential of cytochrome P450 1A (CYP1A) gene in the marine medaka, Oryzias melastigma exposed to water-accommodated fractions (WAFs) of Iranian crude oil.	Abstract
10/30/2008	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Expression of R-ras oncogenes in the hermaphroditic fish Kryptolebias marmoratus, exposed to endocrine disrupting chemicals.	Abstract
04/23/2009	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Endocrine disruptors modulate expression of hepatic choriogenin genes in the hermaphroditic fish, Kryptolebias marmoratus.	Abstract
07/31/2008	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Heat shock protein (Hsp) gene responses of the intertidal copepod Tigriopus japonicus to environmental toxicants.	Abstract
07/18/2010	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Bisphenol A modulates expression of gonadotropin subunit genes in the hermaphroditic fish, Kryptolebias marmoratus.	Abstract
08/07/2010	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Effect of cadmium exposure on expression of antioxidant gene transcripts in the river pufferfish, Takifugu obscurus (Tetraodontiformes).	Abstract
10/20/2011	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Susceptibility to oxidative stress and modulated expression of antioxidant genes in the copper-exposed polychaete Perinereis nuntia.	Abstract
05/22/2013	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Effect of copper exposure on GST activity and on the expression of four GSTs under oxidative stress condition in the monogonont rotifer, Brachionus koreanus.	Abstract
09/08/2009	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Expression profiles of seven glutathione S-transferase (GST) genes in cadmium-exposed river pufferfish (Takifugu obscurus).	Abstract
02/04/2011	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Effects of UV radiation on marine ectotherms in polar regions.	Abstract
06/21/2013	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Role of crustacean hyperglycemic hormone (CHH) in the environmental stressor-exposed intertidal copepod Tigriopus japonicus.	Abstract
01/05/2010	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Molecular characterization and expression of vitellogenin (Vg) genes from the cyclopoid copepod, Paracyclopina nana exposed to heavy metals.	Abstract
03/31/2011	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Response of glutathione S-transferase (GST) genes to cadmium exposure in the marine pollution indicator worm, Perinereis nuntia.	Abstract
09/09/2013	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Effect of pharmaceuticals exposure on acetylcholinesterase (AchE) activity and on the expression of AchE gene in the monogonont rotifer, Brachionus koreanus.	Abstract
12/16/2009	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Cloning and expression of ecdysone receptor (EcR) from the intertidal copepod, Tigriopus japonicus.	Abstract
09/19/2008	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Molecular cloning, phylogenetic analysis and expression of a MAPEG superfamily gene from the pufferfish Takifugu obscurus.	Abstract
10/25/2011	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Expression pattern analysis of DNA repair-related and DNA damage response genes revealed by 55K oligomicroarray upon UV-B irradiation in the intertidal copepod, Tigriopus japonicus.	Abstract
10/18/2010	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Endocrine disrupting chemicals modulate expression of O⁶-methylguanine DNA methyltransferase (O⁶-MGMT) gene in the hermaphroditic fish, Kryptolebias marmoratus.	Abstract
07/08/2010	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Effects of salinity and endocrine-disrupting chemicals on expression of prolactin and prolactin receptor genes in the euryhaline hermaphroditic fish, Kryptolebias marmoratus.	Abstract
10/01/2011	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 8-Oxoguanine DNA glycosylase 1 (OGG1) from the copepod Tigriopus japonicus: molecular characterization and its expression in response to UV-B and heavy metals.	Abstract
03/03/2011	2.6	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP Molecular and biochemical modulation of heat shock protein 20 (Hsp20) gene by temperature stress and hydrogen peroxide (H₂O₂) in the monogonont rotifer, Brachionus sp.	Abstract
09/07/2012	2.6	Annals of hematology Anemia and activities of daily living in the Korean urban elderly population: results from the Korean Longitudinal Study on Health and Aging (KLoSHA).	Abstract
12/18/2012	2.6	The American journal of tropical medicine and hygiene Evaluation of a field-portable DNA microarray platform and nucleic acid amplification strategies for the detection of arboviruses, arthropods, and bloodmeals.	Abstract
09/16/2013	2.6	The American journal of tropical medicine and hygiene Field detection of Tembusu virus in western Thailand by rt-PCR and vector competence determination of select culex mosquitoes for transmission of the virus.	Abstract
12/16/2009	2.6	Leukemia & lymphoma Is inactivation of O6-methylguanine DNA methyltransferase still a favorable prognostic factor of patients with diffuse large B-cell lymphoma in the era of R-CHOP chemotherapy?	Abstract
07/07/2012	2.6	Journal of cancer research and clinical oncology Early neutrophil-to-lymphocyte ratio reduction as a surrogate marker of prognosis in never smokers with advanced lung adenocarcinoma receiving gefitinib or standard chemotherapy as first-line therapy.	Abstract
10/29/2010	2.5	Journal of physics. Condensed matter : an Institute of Physics journal Evidence that small proteins translocate through silicon nitride pores in a folded conformation.	Abstract
10/25/2012	2.5	Clinical orthopaedics and related research Does valgus femoral osteotomy improve femoral head roundness in severe Legg-Calvé-Perthes disease?	Abstract
09/11/2012	2.5	Clinical orthopaedics and related research Validation of the Korean version of the Oxford Knee Score in patients undergoing total knee arthroplasty.	Abstract
10/21/2011	2.5	Clinical orthopaedics and related research Is the dislocation rate higher after bipolar hemiarthroplasty in patients with neuromuscular diseases?	Abstract
07/31/2012	2.5	Life sciences Effect of (E)-2-(3,4-dimethoxyphenyl)-4-oxo-4H-chromen-7-yl-3-(3,4-dimethoxyphenyl) acrylate on the development of atopic dermatitis-like lesions.	Abstract
08/07/2013	2.5	Experimental biology and medicine (Maywood, N.J.) Galangin induces human colon cancer cell death via the mitochondrial dysfunction and caspase-dependent pathway.	Abstract
09/24/2009	2.5	The Journal of neuropsychiatry and clinical neurosciences Association between preoperative anxiety in spinal stenosis patients and abnormal cerebral glucose metabolism: voxel-based statistical analysis of F-18 FDG brain PET.	Abstract
05/11/2011	2.5	Marine pollution bulletin Expression of superoxide dismutase (SOD) genes from the copper-exposed polychaete, Neanthes succinea.	Abstract
11/25/2008	2.5	Biochemical and biophysical research communications An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner.	Abstract
05/22/2010	2.5	Biochemical and biophysical research communications Phosphorylation of p300 by ATM controls the stability of NBS1.	Abstract
11/28/2008	2.5	Biochemical and biophysical research communications A novel role for methyl CpG-binding domain protein 3, a component of the histone deacetylase complex, in regulation of cell cycle progression and cell death.	Abstract
11/10/2009	2.5	Biochemical and biophysical research communications Divalent cations induce a compaction of intrinsically disordered myelin basic protein.	Abstract
04/29/2010	2.5	Experimental & molecular medicine ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response.	Abstract
11/13/2013	2.5	World journal of gastroenterology : WJG Magnifying endoscopy for the diagnosis of specialized intestinal metaplasia in short-segment Barrett's esophagus.	Abstract
03/04/2011	2.4	Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Survival benefit of gastrectomy ± metastasectomy in patients with metastatic gastric cancer receiving chemotherapy.	Abstract
10/18/2013	2.4	Environmental toxicology β-Naphthoflavone induces oxidative stress in the intertidal copepod, Tigriopus japonicus.	Abstract
11/01/2013	2.4	American journal of infection control The impact of a ventilator bundle on preventing ventilator-associated pneumonia: a multicenter study.	Abstract
10/01/2008	2.4	International journal of colorectal disease Evaluation of novel histone deacetylase inhibitors as therapeutic agents for colorectal adenocarcinomas compared to established regimens with the histoculture drug response assay.	Abstract
03/19/2010	2.4	Annals of biomedical engineering The effect of stent porosity and strut shape on saccular aneurysm and its numerical analysis with lattice Boltzmann method.	Abstract
01/23/2009	2.3	Gene The complete mitochondrial genome of the cyclopoid copepod Paracyclopina nana: a highly divergent genome with novel gene order and atypical gene numbers.	Abstract
07/01/2011	2.3	Journal of clinical pathology Comparison of clinical outcome of patients with non-small-cell lung cancer harbouring epidermal growth factor receptor exon 19 or exon 21 mutations.	Abstract
08/06/2008	2.3	Ecotoxicology and environmental safety Differential expression of metallothionein (MT) gene by trace metals and endocrine-disrupting chemicals in the hermaphroditic mangrove killifish, Kryptolebias marmoratus.	Abstract
12/21/2009	2.3	Marine environmental research Modulation of p53 gene expression in the intertidal copepod Tigriopus japonicus exposed to alkylphenols.	Abstract
06/21/2013	2.3	Marine environmental research Expression of three novel cytochrome P450 (CYP) and antioxidative genes from the polychaete, Perinereis nuntia exposed to water accommodated fraction (WAF) of Iranian crude oil and benzo[a]pyrene.	Abstract
03/02/2012	2.3	International journal of systematic and evolutionary microbiology Loktanella litorea sp. nov., isolated from seawater.	Abstract
06/29/2012	2.3	International journal of systematic and evolutionary microbiology Duganella sacchari sp. nov. and Duganella radicis sp. nov., two novel species isolated from rhizosphere of field-grown sugar cane.	Abstract
07/20/2009	2.3	International journal of systematic and evolutionary microbiology Oceanobacillus kapialis sp. nov., from fermented shrimp paste in Thailand.	Abstract
07/22/2009	2.3	International journal of systematic and evolutionary microbiology Paenibacillus cellulositrophicus sp. nov., a cellulolytic bacterium from Thai soil.	Abstract
08/03/2009	2.3	International journal of systematic and evolutionary microbiology Halomonas stevensii sp. nov., Halomonas hamiltonii sp. nov. and Halomonas johnsoniae sp. nov., isolated from a renal care centre.	Abstract
04/22/2011	2.3	International journal of systematic and evolutionary microbiology Patulibacter ginsengiterrae sp. nov., isolated from soil of a ginseng field, and an emended description of the genus Patulibacter.	Abstract
02/26/2009	2.3	International journal of systematic and evolutionary microbiology Paenibacillus thailandensis sp. nov. and Paenibacillus nanensis sp. nov., xylanase-producing bacteria isolated from soil.	Abstract
01/22/2010	2.3	International journal of systematic and evolutionary microbiology Cohnella xylanilytica sp. nov. and Cohnella terrae sp. nov., xylanolytic bacteria from soil.	Abstract
08/20/2010	2.3	International journal of systematic and evolutionary microbiology Pisciglobus halotolerans gen. nov., sp. nov., isolated from fish sauce.	Abstract
11/27/2009	2.3	International journal of systematic and evolutionary microbiology Paenibacillus sputi sp. nov., isolated from the sputum of a patient with pulmonary disease.	Abstract
02/26/2010	2.3	International journal of systematic and evolutionary microbiology Paenibacillus xylanisolvens sp. nov., a xylan-degrading bacterium from soil.	Abstract
09/24/2010	2.3	International journal of systematic and evolutionary microbiology Reclassification of Paenibacillus ginsengisoli as a later heterotypic synonym of Paenibacillus anaericanus.	Abstract
10/14/2011	2.3	International journal of systematic and evolutionary microbiology Cohnella cellulosilytica sp. nov., isolated from buffalo faeces.	Abstract
11/13/2009	2.3	International journal of systematic and evolutionary microbiology Cohnella thailandensis sp. nov., a xylanolytic bacterium from Thai soil.	Abstract
06/30/2009	2.3	International journal of systematic and evolutionary microbiology Gordonia kroppenstedtii sp. nov., a phenol-degrading actinomycete isolated from a polluted stream.	Abstract
03/30/2012	2.3	International journal of systematic and evolutionary microbiology Marivita geojedonensis sp. nov., isolated from seawater.	Abstract
03/19/2010	2.3	International journal of systematic and evolutionary microbiology Fontibacillus panacisegetis sp. nov., isolated from soil of a ginseng field.	Abstract
09/07/2009	2.3	Oncology The role of KRAS mutations in predicting the efficacy of cetuximab-plus-irinotecan therapy in irinotecan-refractory Korean metastatic colorectal cancer patients.	Abstract
07/18/2013	2.3	Physical review. E, Statistical, nonlinear, and soft matter physics Effect of hydrodynamic and fluid-solid interaction forces on the shape and stability of a droplet sedimenting on a horizontal wall.	Abstract
01/11/2010	2.3	Physical review. E, Statistical, nonlinear, and soft matter physics Investigation of heat transfer in turbulent nanofluids using direct numerical simulations.	Abstract
01/09/2012	2.2	Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Cloning of growth hormone, somatolactin, and their receptor mRNAs, their expression in organs, during development, and on salinity stress in the hermaphroditic fish, Kryptolebias marmoratus.	Abstract
03/16/2011	2.2	Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA Synovialization on second-look arthroscopy after anterior cruciate ligament reconstruction using Achilles allograft in active young men.	Abstract
09/16/2010	2.2	Molecules and cells Systems-level analysis of gene expression data revealed NR0B2/SHP as potential tumor suppressor in human liver cancer.	Abstract
09/03/2010	2.2	Geriatrics & gerontology international Donepezil treatment in Alzheimer's disease patients with and without cerebrovascular lesions: a preliminary report.	Abstract
05/22/2008	2.1	Medical oncology (Northwood, London, England) Bevacizumab plus FOLFIRI or FOLFOX as third-line or later treatment in patients with metastatic colorectal cancer after failure of 5-fluorouracil, irinotecan, and oxaliplatin: a retrospective analysis.	Abstract
01/14/2010	2.1	Medical oncology (Northwood, London, England) Three-weekly S-1 plus cisplatin chemotherapy as first-line treatment for advanced gastric cancer.	Abstract
04/16/2011	2.1	Medical oncology (Northwood, London, England) Phase II study of pemetrexed plus oxaliplatin for platinum-resistant advanced or metastatic non-small cell lung cancer patients.	Abstract
06/09/2010	2.1	Medical oncology (Northwood, London, England) Biomarker analysis in patients with advanced gastric cancer treated with S-1 plus cisplatin chemotherapy: orotate phosphoribosyltransferase expression is associated with treatment outcomes.	Abstract
10/11/2008	2.1	Medical oncology (Northwood, London, England) Extramedullary peritoneal hematopoiesis combined with tuberculosis in a patient with primary myelofibrosis.	Abstract
03/22/2012	2.1	Antonie van Leeuwenhoek Shewanella seohaensis sp. nov., isolated from a tidal flat sediment.	Abstract
10/31/2012	2.1	Antonie van Leeuwenhoek Methylobacillus rhizosphaerae sp. nov., a novel plant-associated methylotrophic bacterium isolated from rhizosphere of red pepper.	Abstract
12/13/2010	2.1	Brain & development Uncovered primary seizure foci in Lennox-Gastaut syndrome after corpus callosotomy.	Abstract
04/04/2009	2.1	Blood purification Relationship between extracellular water fraction of total body water estimated by bioimpedance spectroscopy and cardiac troponin T in chronic haemodialysis patients.	Abstract
09/22/2009	2.1	Journal of surgical oncology Technical feasibility and safety of laparoscopy-assisted total gastrectomy in gastric cancer: a comparative study with laparoscopy-assisted distal gastrectomy.	Abstract
04/12/2013	2.1	Phytotherapy research : PTR Fucoidan prevents high-fat diet-induced obesity in animals by suppression of fat accumulation.	Abstract
02/19/2013	2.1	Journal of pharmacological sciences Baicalin from Scutellaria baicalensis impairs Th1 polarization through inhibition of dendritic cell maturation.	Abstract