Engelman,Alan

Institution: Dana-Farber Cancer Institute, USA

Top Collaborators: Koh Y, Matreyek KA, Li X, Krishnan L, Kewalramani VN, Cherepanov P, Jurado KA, Wu X, Ferris AL, Smith SJ, Lee K, Hughes SH, Ballandras-colas A, Dar MJ, Haim H, Wang H, Shun MC, Oztop I, Patel PA, Fuchs JR

Research Interests: Hiv, Hiv-1, Integrase, Virus, DNA, Infection, Human, Human Immunodeficiency Virus, Viral DNA, Cells, Viruses, Epithelium, Human Immunodeficiency Virus Type 1, Lentiviruses, Reverse Transcription, Inhibition, Binding Site, Leukemia, Moloney Murine Leukemia Virus, Murine Leukemia Virus

Publications
Grants

Information and abstracts for author publications
Published Date	Impact	Publication
08/23/2010	9.8	Proceedings of the National Academy of Sciences of the United States of America Structure-based modeling of the functional HIV-1 intasome and its inhibition.	Abstract
04/22/2013	9.8	Proceedings of the National Academy of Sciences of the United States of America Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.	Abstract
10/10/2013	9.1	PLoS pathogens Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity.	Abstract
10/05/2012	8	Nucleic acids research HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.	Abstract
11/26/2013	7.1	Expert reviews in molecular medicine Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.	Abstract
10/19/2009	6.5	Retrovirology Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.	Abstract
10/24/2012	5.4	Journal of virology Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration.	Abstract
01/25/2012	5.4	Journal of virology Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus.	Abstract
01/26/2011	5.4	Journal of virology Differential sensitivities of retroviruses to integrase strand transfer inhibitors.	Abstract
10/21/2009	5.4	Journal of virology The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase.	Abstract
05/18/2011	5.4	Journal of virology The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid.	Abstract
11/08/2010	4.8	Antimicrobial agents and chemotherapy Identification and characterization of persistent intracellular human immunodeficiency virus type 1 integrase strand transfer inhibitor activity.	Abstract
10/05/2012	4.8	The Journal of biological chemistry Retroviral integrase proteins and HIV-1 DNA integration.	Abstract
10/04/2013	4.1	PloS one Biochemical characterization of novel retroviral integrase proteins.	Abstract
04/24/2009	4	Methods (San Diego, Calif.) Mechanistic and pharmacological analyses of HIV-1 integration.	Abstract
01/08/2011	3.4	Virology Structural biology of retroviral DNA integration.	Abstract
10/03/2012	3.3	Expert review of anti-infective therapy Viral latency and potential eradication of HIV-1.	Abstract
03/26/2009	2	Journal of virological methods In vivo biotinylation and capture of HIV-1 matrix and integrase proteins.	Abstract

Grants Recieved by this author
Budget Start	Budget End	Grant Type	Project Cost	Project Title
9/01/2012	8/31/2014	NIH P50: Specialized Center	$445,815	Project 11
6/01/2008	5/31/2014	NIH R37: Method to Extend Research in Time (MERIT) Award	$2,663,783	Biochemical Mechanism of HIV DNA Integration
4/01/2008	3/31/2014	NIH R01: Research Project	$2,694,884	HIV-1 Integrase Structural Biology
3/01/2008	2/28/2014	NIH R01: Research Project	$2,513,724	HIV-1 Preintegration Trafficking and Nuclear Localization