Showing search results for "D'Orazi G"
Tumor, Cancer, Cells, Kinase,
, Hypoxia, Inhibition, Zinc, DNA, Tumors, Cell, Gene, Apoptosis, Growth, Acetylation, siRNA, Treatment, Upregulation, Downregulation, Genes
Information and abstracts for author publications
Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.
Free radical biology & medicine
Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.
Cell cycle (Georgetown, Tex.)
Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs.
Cell cycle (Georgetown, Tex.)
HIPK2-a therapeutical target to be (re)activated for tumor suppression: role in p53 activation and HIF-1α inhibition.
Cell death & disease
Glucose restriction induces cell death in parental but not in homeodomain-interacting protein kinase 2-depleted RKO colon cancer cells: molecular mechanisms and implications for tumor therapy.
HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation.
Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation.
Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha.
Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo.
Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.
Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis.
HIPK2 modulates p53 activity towards pro-apoptotic transcription.
Experimental cell research
Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc.
Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells.
Cancer biology & therapy
HIPK2 downregulates vimentin and inhibits breast cancer cell invasion.
Journal of experimental & clinical cancer research : CR
A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells.
JoVE Monthly Highlights: September 2018
JoVE Monthly Highlights: Septe…
Growing Magnetotactic Bacteria of the Genus
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Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
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Rigid Embedding of Fixed and Stained, Whole, Millimeter-Scale Specimens for Section-free 3D Histology by Micro-Computed Tomography
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Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1
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Characterization of Human Monocyte Subsets by Whole Blood Flow Cytometry Analysis
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A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
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Use of Principal Components for Scaling Up Topographic Models to Map Soil Redistribution and Soil Organic Carbon
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